Tunicamycin V
Based on 2 publication(s) in Google Scholar
Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35?μM. Tunicamycin V has antibacterial activties.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 66054-36-2
- Formula: C39H64N4O16
- Molecular Weight:844.94
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tunicamycin V
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Biological Activity
IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))[1]
Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 66054-36-2
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Appearance Solid
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Molecular Weight 844.94
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Formula C39H64N4O16
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@@H](CC[C@H]([C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC(NC3=O)=O)O2)O)O[C@@H](O[C@@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H]1NC(/C=C/CCCCCCCCCC(C)C)=O
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Synonyms
Tunicamycin A
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Structure Classification
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Initial Source
Streptomyces xinghaiensis SCSIO S15077
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Lett
Pharmacological suppression of HHLA2 glycosylation restores anti-tumor immunity in colorectal cancer. [Abstract]2024 May 1:589:216819. PMID: 38522775 -
Cancer Lett
Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer. [Abstract]2021 Oct 10:518:82-93. PMID: 34153400
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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