1. Anti-infection
  2. Bacterial
  3. Tunicamycin V

Tunicamycin V  (Synonyms: Tunicamycin A)

Cat. No.: HY-N8395 Purity: ≥95.0%
COA Handling Instructions

Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35 μM. Tunicamycin V has antibacterial activties.

For research use only. We do not sell to patients.

Tunicamycin V Chemical Structure

Tunicamycin V Chemical Structure

CAS No. : 66054-36-2

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Based on 1 publication(s) in Google Scholar

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  • Customer Review

Description

Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35 μM. Tunicamycin V has antibacterial activties[1][2].

IC50 & Target

IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))[1]

In Vitro

Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

844.94

Formula

C39H64N4O16

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@@H](CC[C@H]([C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC(NC3=O)=O)O2)O)O[C@@H](O[C@@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H]1NC(/C=C/CCCCCCCCCC(C)C)=O

Structure Classification
Initial Source

Streptomyces xinghaiensis SCSIO S15077

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

References
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Tunicamycin V Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tunicamycin V
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