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PAT-1251 Hydrochloride 

Cat. No.: HY-107422A
Handling Instructions

PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively).

For research use only. We do not sell to patients.

PAT-1251 Hydrochloride Chemical Structure

PAT-1251 Hydrochloride Chemical Structure

CAS No. : 2098884-53-6

Size Price Stock
5 mg USD 650 Get quote
10 mg USD 950 Get quote
25 mg USD 1950 Get quote
50 mg USD 2950 Get quote
100 mg USD 4500 Get quote

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Other In-stock Forms of PAT-1251 Hydrochloride:

Other Forms of PAT-1251 Hydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively).

IC50 & Target

IC50: 0.10 μM (Mouse LOXL2), 0.12 μM (Rat LOXL2), 0.16 μM (Dog LOXL2), 0.71 μM (hLOXL2), 1.17 μM (hLOXL3)[1]

In Vitro

PAT-1251 is a lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with <10% inhibition at 10 μM[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2946 mL 11.4732 mL 22.9463 mL
5 mM 0.4589 mL 2.2946 mL 4.5893 mL
10 mM 0.2295 mL 1.1473 mL 2.2946 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

435.80

Formula

C₁₈H₁₈ClF₄N₃O₃

CAS No.

2098884-53-6

SMILES

O=C(C1=CC=CC(OC2=NC(C(F)(F)F)=CC(CN)=C2)=C1)N3C[[email protected]@H](F)[[email protected]](O)C3.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PAT-1251 Hydrochloride
Cat. No.:
HY-107422A
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PAT-1251 Hydrochloride

Cat. No.: HY-107422A