Abcc8 - ATP binding cassette subfamily C member 8 Gene

Rattus norvegicus

Also known as Sur; Sur1

Gene ID: 25559 | Gene type: protein coding

About Abcc8

Summary

Predicted to enable ATPase-coupled cation transmembrane transporter activity; Potassium Channel activity; and transmembrane transporter binding activity. Involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in sarcolemma and synaptic vesicle membrane. Part of inward rectifying Potassium Channel. Colocalizes with mitochondrion. Used to study brain edema; cardiac arrest; hypoglycemia; and middle cerebral artery infarction. Biomarker of Parkinsonism; sciatic neuropathy; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcc8 Products(3)

mRNA	Protein	Name
NM_001412033.1	NP_001398962.1	ATP-binding cassette sub-family C member 8 isoform 2
NM_001412034.1	NP_001398963.1	ATP-binding cassette sub-family C member 8 isoform 3
NM_013039.3	NP_037171.2	ATP-binding cassette sub-family C member 8 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21527399	RGD
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23828271	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	24114458	RGD
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23149556	RGD
involved in negative regulation of blood-brain barrier permeability	IMP IMP: Inferred from mutant phenotype	18854840	RGD
involved in negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	23149556	RGD
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	15163199	RGD
involved in negative regulation of low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	23828271	RGD
involved in negative regulation of neuroblast migration	IMP IMP: Inferred from mutant phenotype	23149556	RGD
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	23149556	RGD
involved in positive regulation of potassium ion transport	IDA IDA: Inferred from direct assay	15962003	RGD
involved in positive regulation of tight junction disassembly	IMP IMP: Inferred from mutant phenotype	23633925	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18854840	RGD
involved in positive regulation of uterine smooth muscle relaxation	IMP IMP: Inferred from mutant phenotype	25891870	RGD
involved in positive regulation of voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	12183335	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	18084728	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17285300	RGD
involved in response to pH	IDA IDA: Inferred from direct assay	15613469	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17174476	RGD
involved in response to zinc ion	IDA IDA: Inferred from direct assay	15613469	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	24114458	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	24114458	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14645230	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15647111	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	14645230	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family C member 8

ATP-binding cassette transporter sub-family C member 8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ATP-binding cassette, subfamily C (CFTR/MRP), member 8	sulfonylurea receptor 1
sulphonylurea receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00066	ABCC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc8	NCBI	NCBI:6833

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