Abcc8 - ATP binding cassette subfamily C member 8 Gene

Also Known as Sur; Sur1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25559

Summary

Predicted to enable ATPase-coupled cation transmembrane transporter activity; Potassium Channel activity; and transmembrane transporter binding activity. Involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in sarcolemma and synaptic vesicle membrane. Part of inward rectifying Potassium Channel. Colocalizes with mitochondrion. Used to study brain edema; cardiac arrest; hypoglycemia; and middle cerebral artery infarction. Biomarker of Parkinsonism; sciatic neuropathy; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcc8 Products (3)

mRNA Protein Name
NM_001412033.1 NP_001398962.1 ATP-binding cassette sub-family C member 8 isoform 2
NM_001412034.1 NP_001398963.1 ATP-binding cassette sub-family C member 8 isoform 3
NM_013039.3 NP_037171.2 ATP-binding cassette sub-family C member 8 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
21527399 RGD
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23828271 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
24114458 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
23149556 RGD
involved in negative regulation of blood-brain barrier permeability IMP
IMP: Inferred from mutant phenotype
18854840 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
23149556 RGD
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
15163199 RGD
involved in negative regulation of low-density lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
23828271 RGD
involved in negative regulation of neuroblast migration IMP
IMP: Inferred from mutant phenotype
23149556 RGD
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
23149556 RGD
involved in positive regulation of potassium ion transport IDA
IDA: Inferred from direct assay
15962003 RGD
involved in positive regulation of tight junction disassembly IMP
IMP: Inferred from mutant phenotype
23633925 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18854840 RGD
involved in positive regulation of uterine smooth muscle relaxation IMP
IMP: Inferred from mutant phenotype
25891870 RGD
involved in positive regulation of voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
12183335 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
18084728 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17285300 RGD
involved in response to pH IDA
IDA: Inferred from direct assay
15613469 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17174476 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
15613469 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
24114458 RGD
Cellular Component GO Annotation Evidence References Source
part of inward rectifying potassium channel IDA
IDA: Inferred from direct assay
24114458 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14645230 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15647111 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
14645230 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 8

  • ATP-binding cassette transporter sub-family C member 8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8

  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8

  • sulfonylurea receptor 1

  • sulphonylurea receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00066 ABCC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc8 NCBI NCBI:6833