2. Gene
  3. Pms2 - PMS1 homolog 2, mismatch repair system component Gene

Pms2 - PMS1 homolog 2, mismatch repair system component Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 288479 | Gene type: protein coding

About Pms2

Summary

Predicted to enable ATP hydrolysis activity and single base insertion or deletion binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal Cancer type 4; mismatch repair Cancer syndrome; ovarian cancer; and urinary bladder Cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Apr 2022]

Pms2 Products(2)

mRNA Protein Name
NM_001105908.1 NP_001099378.1 mismatch repair endonuclease PMS2 isoform 2
NM_001399795.1 NP_001386724.1 mismatch repair endonuclease PMS2 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11056294 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mismatch repair endonuclease PMS2

PMS2 postmeiotic segregation increased 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-173455 NP1867 Inhibitor / Unkown
HY-RS10773 PMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pms2 NCBI NCBI:5395