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DCDC1 - doublecortin domain containing 1 Gene

Also Known as DCDC5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 341019

About DCDC1

Cytogenetic location: 11p14.1-p13 Genomic coordinates (GRCh38): 11:30,863,603-31,369,739 (from NCBI)

This gene has 12 transcripts (splice variants) and 57 orthologues. Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 3 other tissues.

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

DCDC1 Products (5)

mRNA	Protein	Name
NM_001367979.1	NP_001354908.1	doublecortin domain-containing protein 1 isoform 4
NM_001387274.1	NP_001374203.1	doublecortin domain-containing protein 1 isoform 6
NM_001387275.1	NP_001374204.1	doublecortin domain-containing protein 1 isoform 7
NM_020869.4	NP_065920.2	doublecortin domain-containing protein 1 isoform 3
NM_181807.4	NP_861523.2	doublecortin domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	22159412	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22159412	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	22159412	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Flemming body	IDA IDA: Inferred from direct assay	22159412	GOA
located in midbody	IDA IDA: Inferred from direct assay	22159412	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	22159412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
doublecortin domain-containing protein 1	doublecortin domain-containing 5 protein

Related Diseases

Diseases	Alias
Brachyolmia Type 4 With Mild Epiphyseal And Metaphyseal Changes	Spondyloepimetaphyseal Dysplasia, Pakistani Type Spondyloepimetaphyseal Dysplasia, Papss2 Type BCYM4 Semd, Pakistani Type Spondylodysplasia And Premature Pubarche Brachyolmia 4 With Mild Epiphyseal And Metaphyseal Changes Spondyloepimetaphyseal Dysplasia Pakistani Type Semd Pakistani Type Spondylometaepiphyseal Dysplasia Pakistani Type Brachyolmia, Type 4, With Mild Epiphyseal And Metaphyseal Changes
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p
Iris Disease	Iris Diseases
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Coloboma Of Optic Nerve	Morning Glory Disc Anomaly Coloboma Of Optic Disc Morning Glory Syndrome Ectasic Coloboma Coloboma Of Optic Papilla Congenital Coloboma Of The Optic Nerve Optic Nerve Coloboma Optic Nerve Head Pits, Bilateral Congenital Volubilis Syndrome COLON Coloboma Of Optic Disc, Unspecified Eye Congenital Coloboma Of Optic Disc Optic Disk Coloboma
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03573	DCDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCDC1	VGNC	VGNC:108127
Canis familiaris	DCDC1	VGNC	VGNC:106595
Rattus norvegicus	DCDC1	RGD	RGD:1562221