country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MYO9A - myosin IXA Gene

Also Known as CMS24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4649

About MYO9A

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:71,822,291-72,118,600 (from NCBI)

This gene has 21 transcripts (splice variants), 287 orthologues, 43 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 12.9), thyroid (RPKM 5.9) and 24 other tissues.

Summary

This gene encodes a member of the Myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

MYO9A Products (1)

mRNA	Protein	Name
NM_006901.4	NP_008832.2	unconventional myosin-IXa

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15644318	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22891260	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO9A Protein Structure

Myosin_head

RhoGAP

0
400
800
1200
1600
2000
2400
2548 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-IXa	myosin-IXa

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 24, Presynaptic	CMS24
Presynaptic Congenital Myasthenic Syndromes	Presynaptic Congenital Myasthenic Syndrome Congenital Myasthenic Syndromes, Presynaptic
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Myopathy, Myofibrillar, 8	Myofibrillar Myopathy 8 MFM8 Myopathy, Myofibrillar, Type 8
Myopathy, Centronuclear, 4	CNM4 Centronuclear Myopathy 4 Congenital Myopathy With Internal Nuclei And Atypical Cores Centronuclear Myopathy Type 4 Myopathy, Centronuclear, Type 4
Bardet-Biedl Syndrome 7	BBS7 Bardet-Biedl Syndrome, Type 7
Myopathy, Centronuclear, 5	CNM5 Centronuclear Myopathy 5 Myopathy, Centronuclear, Type 5
Neuronopathy, Distal Hereditary Motor, Type Viia	HMN7A Hmn Viia Dhmn7a Neuropathy, Distal Hereditary Motor, Type Viia Dhmnvp Harper-Young Myopathy Distal Hereditary Motor Neuronopathy Type 7a Distal Hereditary Motor Neuropathy Type Viia Neuronopathy, Distal Hereditary Motor, Type 7a Spinal Muscular Atrophy, Distal, With Vocal Cord Paralysis Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7a Harper-Young Myopath Neuronopathy, Distal Hereditary Motor, 7a Distal Hereditary Motor Neuronopathy Type Viia Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Neuropathy, Motor, Distal, Hereditary, Type Viia
Myopathy, Myofibrillar, 7	Myofibrillar Myopathy 7 MFM7 Kyphosis-Lateral Tongue Atrophy-Myofibrillar Myopathy Syndrome Myopathy, Myofibrillar, Type 7
Myasthenic Syndrome, Congenital, 14	Congenital Myasthenic Syndrome 14 CMS14 Cmsta3 Myasthenic Syndrome, Congenital, With Tubular Aggregates 3 Myasthenic Syndrome, Congenital, 14, With Tubular Aggregates Congenital Myasthenic Syndrome 14, With Tubular Aggregates Congenital Myasthenic Syndrome With Tubular Aggregates 3 Myasthenic Syndrome, Congenital, With Tubular Aggregates, 3 Myasthenic Syndrome, Congenital, Type 14, With Tubular Aggregates
Spinocerebellar Ataxia, Autosomal Recessive 10	SCAR10 Autosomal Recessive Spinocerebellar Ataxia 10 Adult-Onset Autosomal Recessive Cerebellar Ataxia Autosomal Recessive Spinocerebellar Ataxia Type 10 Spinocerebellar Ataxia, Autosomal Recessive, 10 Ataxia, Spinocerebellar, Autosomal Recessive, Type 10
Chromosome 17q23.1-Q23.2 Deletion Syndrome	17q23.1q23.2 Microdeletion Syndrome 17q23.1-Q23.2 Microdeletion Syndrome Del(17)(Q23.1q23.2) Monosomy 17q23.1q23.2 Monosomy 17q23.1-Q23.2
Myasthenic Syndrome, Congenital, 6, Presynaptic	Familial Infantile Myasthenia CMS6 Cmsea Congenital Myasthenic Syndrome 6 Familial Infantile Myasthenia Gravis 2 Fimg2 Myasthenic Syndrome, Congenital, Associated With Episodic Apnea Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea Congenital Myasthenic Syndrome Type Ia2, Formerly Cms1a2, Formerly Cms Ia2, Formerly Myasthenia, Familial Infantile, Formerly Fim, Formerly Myasthenia Gravis, Familial Infantile, 2, Formerly Fimg2, Formerly Cms Ia2 Cms1a2 Congenital Myasthenic Syndrome 6, Presynaptic Congenital Myasthenic Syndrome Type Ia2 Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea Fim Cms1a Cms-Ea Cms Ia Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea Congenital Myasthenic Syndrome Type 1a Congenital Myasthenic Syndrome Type Ia Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Neuromuscular Junction Disease	Neuromuscular Junction Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08952	MYO9A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYO9A	RGD	RGD:621395
Mus musculus	MYO9A	MGD	MGI:107735
Canis familiaris	MYO9A	VGNC	VGNC:43574
Felis catus	MYO9A	VGNC	VGNC:68401
Bos taurus	MYO9A	VGNC	VGNC:97290
Macaca mulatta	MYO9A	VGNC	VGNC:75120
Others	MYO9A	NCBI