KCTD3 - potassium channel tetramerization domain containing 3 Gene

Homo sapiens

Also known as NY-REN-45

Gene ID: 51133 | Gene type: protein coding

About KCTD3

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:215,567,304-215,621,807 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 47.4), small intestine (RPKM 24.0) and 25 other tissues.

Summary

This gene encodes a member of the Potassium Channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

KCTD3 Products(3)

mRNA	Protein	Name
NM_001319294.2	NP_001306223.1	BTB/POZ domain-containing protein KCTD3 isoform 2
NM_001319295.2	NP_001306224.1	BTB/POZ domain-containing protein KCTD3 isoform 3
NM_016121.5	NP_057205.2	BTB/POZ domain-containing protein KCTD3 isoform 1

KCTD3 Protein Structure

BTB_2

0
200
400
600
815 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing protein KCTD3

NY-REN-45 antigen

Related Diseases

Diseases

Alias

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07195	KCTD3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCTD3	MGD	MGI:2444629
Macaca mulatta	KCTD3	VGNC	VGNC:73875
Bos taurus	KCTD3	VGNC	VGNC:97280
Felis catus	KCTD3	VGNC	VGNC:63062
Canis familiaris	KCTD3	VGNC	VGNC:42307
Rattus norvegicus	KCTD3	RGD	RGD:1310658

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