Ift122 - intraflagellar transport 122 Gene

Also Known as sopb; Wdr10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81896

Summary

Involved in several processes, including cilium organization; embryonic morphogenesis; and protein localization to organelle. Acts upstream of or within several processes, including embryonic morphogenesis; non-motile cilium assembly; and smoothened signaling pathway. Located in several cellular components, including ciliary basal body; ciliary base; and photoreceptor connecting cilium. Part of intraciliary transport particle A. Is expressed in choroid plexus; dorsal root ganglion; genitourinary system; olfactory epithelium; and pituitary gland. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Apr 2022]

Ift122 Products (2)

mRNA Protein Name
NM_001167763.1 NP_001161235.1 intraflagellar transport protein 122 homolog isoform 2
NM_031177.4 NP_112454.2 intraflagellar transport protein 122 homolog isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
19000668 MGI
acts upstream of or within cilium assembly IGI
IGI: Inferred from genetic interaction
22689656 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
22689656 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
19000668 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
21552265 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
15755804 MGI
involved in embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
19000668 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
28778798 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
15755804 MGI
involved in embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
19000668 MGI
involved in embryonic heart tube left/right pattern formation IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in establishment of protein localization to organelle IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in intraciliary anterograde transport IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in intraciliary retrograde transport IMP
IMP: Inferred from mutant phenotype
21209331 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
involved in limb development IMP
IMP: Inferred from mutant phenotype
19000668 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
28778798 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
28778798 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21209331 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
19000668 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21703454 MGI
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
21209331 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
22689656 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
22689656 MGI
involved in spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
21209331 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
21209331 MGI
located in ciliary base IDA
IDA: Inferred from direct assay
21209331 MGI
located in cilium IDA
IDA: Inferred from direct assay
21209331 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21209331 MGI
part of intraciliary transport particle A IDA
IDA: Inferred from direct assay
20889716 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
19208653 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 122 homolog

  • WD repeat domain 10

  • WD repeat-containing protein 10

  • intraflagellar transport 122 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06598 IFT122 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift122 NCBI NCBI:55764