Ift122 - intraflagellar transport 122 Gene

Mus musculus

Also known as sopb; Wdr10

Gene ID: 81896 | Gene type: protein coding

About Ift122

Summary

Involved in several processes, including cilium organization; embryonic morphogenesis; and protein localization to organelle. Acts upstream of or within several processes, including embryonic morphogenesis; non-motile cilium assembly; and smoothened signaling pathway. Located in several cellular components, including ciliary basal body; ciliary base; and photoreceptor connecting cilium. Part of intraciliary transport particle A. Is expressed in choroid plexus; dorsal root ganglion; genitourinary system; olfactory epithelium; and pituitary gland. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Apr 2022]

Ift122 Products(2)

mRNA	Protein	Name
NM_001167763.1	NP_001161235.1	intraflagellar transport protein 122 homolog isoform 2
NM_031177.4	NP_112454.2	intraflagellar transport protein 122 homolog isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	19000668	MGI
acts upstream of or within cilium assembly	IGI IGI: Inferred from genetic interaction	22689656	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	22689656	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	19000668	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	21552265	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15755804	MGI
involved in embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	19000668	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	28778798	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	15755804	MGI
involved in embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	19000668	MGI
involved in embryonic heart tube left/right pattern formation	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in establishment of protein localization to organelle	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in intraciliary anterograde transport	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	19000668	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	28778798	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	28778798	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21209331	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	19000668	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21703454	MGI
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within receptor clustering	IGI IGI: Inferred from genetic interaction	22689656	MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	22689656	MGI
involved in spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	21209331	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	21209331	MGI
located in ciliary base	IDA IDA: Inferred from direct assay	21209331	MGI
located in cilium	IDA IDA: Inferred from direct assay	21209331	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21209331	MGI
part of intraciliary transport particle A	IDA IDA: Inferred from direct assay	20889716	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	19208653	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 122 homolog

WD repeat domain 10	WD repeat-containing protein 10
intraflagellar transport 122 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06598	IFT122 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ift122	NCBI	NCBI:55764

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