TBC1D8 - TBC1 domain family member 8 Gene

Also Known as AD3; VRP; HBLP1; GRAMD8; TBC1D8A

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 11138

About TBC1D8

This gene has 10 transcripts (splice variants), 197 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 11.3), heart (RPKM 10.6) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

TBC1D8 Products (2)

mRNA Protein Name
NM_001102426.3 NP_001095896.1 TBC1 domain family member 8 isoform 2
NM_001330348.2 NP_001317277.1 TBC1 domain family member 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence 参考文献 由来
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D8 Protein Structure

GRAM

GRAM: GRAM domain (146 - 211)

GRAM

GRAM: GRAM domain (286 - 352)

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (509 - 711)

  • 0
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  • 1000
  • 1140 a.a.
Protein Preferred Names Protein Names

TBC1 domain family member 8

  • BUB2-like protein 1

TBC1D8 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TBC1D8 O95759 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra
TBC1D8 O95759 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
TBC1D8 O95759 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Autosomal Dominant Nonsyndromic Deafness 78

  • Dfna78
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14247 TBC1D8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14248 TBC1D8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus TBC1D8 VGNC VGNC:65989
Canis familiaris TBC1D8 VGNC VGNC:47151
Bos taurus TBC1D8 VGNC VGNC:35645
Macaca mulatta TBC1D8 VGNC VGNC:78153
Rattus norvegicus TBC1D8 RGD RGD:1595491
Mus musculus TBC1D8 MGD MGI:1927225
Others TBC1D8 NCBI