134867-96-2
Chemical Structure
G256 dihydrochloride
- CAS. Nr.: 134867-96-2
- Formula:C14H16Cl3N5
- Molecular Weight:360.67
IUPAC Name: (Z)-2-((2-amino-5-chlorophenyl)(phenyl)methylene)hydrazine-1-carboximidamide dihydrochloride
InChIKey: CFYLXZYRXHKYPX-SJNXHXLPSA-N
SMILES: N=C(N)N/N=C(C1=CC=CC=C1)\C2=C(N)C=CC(Cl)=C2.Cl.Cl
Biological Activity: G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias[1].
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G256 dihydrochloride | G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias. | |||||||||||||||||||||
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Keywords
