150972-72-8
Chemical Structure
7,8-Didehydrocimigenol
- CAS. Nr.: 150972-72-8
- Formula:C30H46O5
- Molecular Weight:486.68
IUPAC Name: (2aR,4S,6aR,7aR,9aR,9bR,10R,12R,13S,14aS,15R,15aR)-13-(2-hydroxypropan-2-yl)-3,3,9a,10,15a-pentamethyl-2,2a,3,4,5,6,8,9,9a,9b,10,11,12,13,15,15a-hexadecahydro-7H-12,14a-epoxycyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]oxepine-4,15-diol
InChIKey: VFWGQUZLHBLDFF-OSIIPQMASA-N
SMILES: C[C@]12C3=CC[C@](C(C)([C@H](CC4)O)C)([H])[C@]54[C@@]3(CC[C@@]1([C@]6([H])[C@@]7(O[C@@H]([C@H](O7)C(C)(O)C)C[C@H]6C)[C@@H]2O)C)C5
Biological Activity: 7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].
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7,8-Didehydrocimigenol | 7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis. | |||||||||||||||||||||
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Keywords
