2834106-56-6
2834106-56-6
Chemical Structure
GPX4-IN-24
- CAS. Nr.: 2834106-56-6
- Formula:C31H35N7O4
- Molecular Weight:569.65
InChIKey: NLFBXDQYYUQAFB-UHFFFAOYSA-N
SMILES: O=C(C(NCCC1=NC=CC=C1)=O)C2=CNC(N=C3)=C2C=C3C4=CC=C(N5CCC(NC(OC(C)(C)C)=O)CC5)N=C4
Biological Activity: GPX4-IN-24 is an orally active glutathione peroxidase 4 (GPX4) inhibitor with a human IC50 of 10.90 μM, human Kd of 10.04 μM. GPX4-IN-24 suppresses GPX4 enzymatic activity, disrupts redox homeostasis, drives lipid peroxidation, promotes lipid peroxidation, and induces ferroptosis. GPX4-IN-24 can be used for the research of triple-negative breast cancer[1].
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GPX4-IN-24 | GPX4-IN-24 is an orally active glutathione peroxidase 4 (GPX4) inhibitor with a human IC50 of 10.90 μM, human Kd of 10.04 μM. GPX4-IN-24 suppresses GPX4 enzymatic activity, disrupts redox homeostasis, drives lipid peroxidation, promotes lipid peroxidation, and induces ferroptosis. GPX4-IN-24 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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References
Keywords
