2915280-95-2
Chemical Structure
RIPK1/RIPK3-PPI-IN-1
- CAS. Nr.: 2915280-95-2
- Formula:C27H20F2N6O3S
- Molecular Weight:546.55
InChIKey: LSMXQJKLPSTCQR-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC=C(OC3=CC=C(C(NC(C4=NC(CC5=C(C=CC=C5)F)=NN4)=O)=C3)F)C=C2S1)C6CC6
Biological Activity: RIPK1/RIPK3-PPI-IN-1 is an orally active dual-target inhibitor of RIPK1/RIPK3, with a Kd value of 2.4 nM for RIPK1 and 24 nM for RIPK3. RIPK1/RIPK3-PPI-IN-1 inhibits the phosphorylation of RIPK1, RIPK3 and MLKL, thereby suppressing necroptosis. RIPK1/RIPK3-PPI-IN-1 restores body temperature, improves survival rate, and reduces IL-1β/IL-6 levels in serum and multiple organs of Mus musculus, thus alleviating TNF-α-induced systemic inflammatory response syndrome. RIPK1/RIPK3-PPI-IN-1 can be used in research related to systemic inflammatory response syndrome[1].
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RIPK1/RIPK3-PPI-IN-1 | RIPK1/RIPK3-PPI-IN-1 is an orally active dual-target inhibitor of RIPK1/RIPK3, with a Kd value of 2.4 nM for RIPK1 and 24 nM for RIPK3. RIPK1/RIPK3-PPI-IN-1 inhibits the phosphorylation of RIPK1, RIPK3 and MLKL, thereby suppressing necroptosis. RIPK1/RIPK3-PPI-IN-1 restores body temperature, improves survival rate, and reduces IL-1β/IL-6 levels in serum and multiple organs of Mus musculus, thus alleviating TNF-α-induced systemic inflammatory response syndrome. RIPK1/RIPK3-PPI-IN-1 can be used in research related to systemic inflammatory response syndrome. | |||||||||||||||||||||
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Keywords
