3024011-99-9
Chemical Structure
LATS1/2-IN-1
- CAS. Nr.: 3024011-99-9
- Formula:C26H31F2N3O3S
- Molecular Weight:503.60
IUPAC Name: 4-((3R,4s,5S)-4-(2-fluoro-4-(3-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-methylphenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide
InChIKey: VRTKPUWWRHXPMG-KQESFQHQSA-N
SMILES: O=S1(CCC(N2C[C@@H](C)[C@](O)(C3=C(C)C=C(C4=C5C(NC=C5F)=NC=C4)C=C3F)[C@@H](C)C2)CC1)=O
Biological Activity: LATS1/2-IN-1 is a potent and selective LATS1 and LATS2 inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and LATS2 with IC50 values of 4.4 nM and 5.5 nM as determined via r33P functional assay. LATS1/2-IN-1 displays cellular IC50 values of 136 nM for LATS1 and 36.0 nM for LATS2 as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing[1].
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LATS1/2-IN-1 | LATS1/2-IN-1 is a potent and selective LATS1 and LATS2 inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and LATS2 with IC50 values of 4.4 nM and 5.5 nM as determined via r33P functional assay. LATS1/2-IN-1 displays cellular IC50 values of 136 nM for LATS1 and 36.0 nM for LATS2 as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing. | |||||||||||||||||||||
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Keywords
