Ift140 - intraflagellar transport 140 Gene

Also Known as Tce5; Wdtc2; mKIAA0590

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106633

Summary

Acts upstream of or within several processes, including cilium organization; embryonic organ development; and nervous system development. Located in Cytoskeleton and photoreceptor cell cilium. Part of intraciliary transport particle A. Is expressed in diaphragm; lung; metanephros; and retina. Used to study asphyxiating thoracic dystrophy 1 and short-rib thoracic dysplasia 9 with or without polydactyly. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Apr 2022]

Ift140 Products (6)

mRNA Protein Name
NM_001410317.1 NP_001397246.1 intraflagellar transport protein 140 homolog isoform 2
NM_001410318.1 NP_001397247.1 intraflagellar transport protein 140 homolog isoform 2
NM_001410319.1 NP_001397248.1 intraflagellar transport protein 140 homolog isoform 1
NM_001410320.1 NP_001397249.1 intraflagellar transport protein 140 homolog isoform 3
NM_001410321.1 NP_001397250.1 intraflagellar transport protein 140 homolog isoform 4
NM_134126.4 NP_598887.3 intraflagellar transport protein 140 homolog isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
22282595 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within embryonic brain development IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within intraciliary retrograde transport IMP
IMP: Inferred from mutant phenotype
24009529 MGI
acts upstream of or within intraciliary transport IMP
IMP: Inferred from mutant phenotype
24619649 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
24009529 MGI
acts upstream of or within neural tube patterning IMP
IMP: Inferred from mutant phenotype
24009529 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
24009529 MGI
acts upstream of or within photoreceptor cell outer segment organization IMP
IMP: Inferred from mutant phenotype
24619649 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
24009529 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in axoneme IDA
IDA: Inferred from direct assay
20368623 MGI
located in centriole IDA
IDA: Inferred from direct assay
29487109 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
23418020 MGI
located in cilium IDA
IDA: Inferred from direct assay
20368623 MGI
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
24619649 MGI
part of intraciliary transport particle A IDA
IDA: Inferred from direct assay
20889716 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
24009529 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
20368623 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 140 homolog

  • T-complex expressed gene 5

  • WD and tetratricopeptide repeats 2

  • WD and tetratricopeptide repeats protein 2

  • intraflagellar transport 140 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06599 IFT140 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift140 NCBI NCBI:9742