Slc8a3 - solute carrier family 8 (sodium/calcium exchanger), member 3 Gene

Also Known as Ncx3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110893

Summary

Enables calcium:sodium antiporter activity and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and nervous system development. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; modulation of excitatory postsynaptic potential; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including mitochondrial outer membrane; postsynaptic density; and sarcolemma. Is integral component of plasma membrane. Is expressed in several structures, including bone; brain; foregut; genitourinary system; and trachea. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc8a3 Products (2)

mRNA Protein Name
NM_001167920.1 NP_001161392.1 sodium/calcium exchanger 3 isoform 1 precursor
NM_080440.3 NP_536688.2 sodium/calcium exchanger 3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium:monoatomic cation antiporter activity IDA
IDA: Inferred from direct assay
8798769 MGI
enables calcium:sodium antiporter activity IMP
IMP: Inferred from mutant phenotype
14722618 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14722618 MGI
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
24101730 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
14722618 MGI
involved in learning IMP
IMP: Inferred from mutant phenotype
21593315 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
29274751 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
21593315 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
21593315 MGI
acts upstream of or within metal ion transport IDA
IDA: Inferred from direct assay
8798769 MGI
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
24101730 MGI
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24101730 MGI
acts upstream of or within modulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
21959935 MGI
acts upstream of or within negative regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21959935 MGI
involved in regulation of skeletal muscle contraction IMP
IMP: Inferred from mutant phenotype
14722618 MGI
involved in sodium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14722618 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
29274751 MGI
Cellular Component GO Annotation Evidence References Source
located in axon terminus IMP
IMP: Inferred from mutant phenotype
29274751 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
24101730 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
24101730 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
14722618 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
24101730 MGI
located in postsynaptic density IMP
IMP: Inferred from mutant phenotype
29274751 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
14722618 MGI
located in synapse IDA
IDA: Inferred from direct assay
29274751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/calcium exchanger 3

  • Na(+)/Ca(2+)-exchange protein 3

  • solute carrier family 8 member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13339 SLC8A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc8a3 NCBI NCBI:6547