Adcy6 - adenylate cyclase 6 Gene

Also Known as AC6; ACVI; ADCYB

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25289

Summary

Enables several functions, including SNARE binding activity; calcium- and calmodulin-responsive Adenylate Cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Located in endosome; membrane raft; and microvillus membrane. Colocalizes with sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (Adenylate Cyclase 6). [provided by Alliance of Genome Resources, Apr 2022]

Adcy6 Products (2)

mRNA Protein Name
NM_001270785.1 NP_001257714.1 adenylate cyclase type 6 isoform 1
NM_012821.5 NP_036953.5 adenylate cyclase type 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables SNARE binding IDA
IDA: Inferred from direct assay
21986494 RGD
enables adenylate cyclase activity IDA
IDA: Inferred from direct assay
11738086 RGD
enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
IDA: Inferred from direct assay
10894801 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15385642 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12748066 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cAMP biosynthetic process IDA
IDA: Inferred from direct assay
10894801 RGD
involved in cAMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
10866989 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
16166080 RGD
involved in maintenance of protein location in plasma membrane IMP
IMP: Inferred from mutant phenotype
21986494 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
21986494 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in endosome IDA
IDA: Inferred from direct assay
17010343 RGD
located in membrane IDA
IDA: Inferred from direct assay
15385642 RGD
located in microvillus membrane IDA
IDA: Inferred from direct assay
10866989 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21986494 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate cyclase type 6

  • ATP pyrophosphate-lyase 6

  • adenylate cyclase type VI

  • adenylyl cyclase 6

  • ca(2+)-inhibitable adenylyl cyclase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00332 ADCY6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcy6 NCBI NCBI:112