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Eif2ak4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

Also Known as GCN2; MGCN2; 2610011M03

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27103

Summary

Enables eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in several processes, including GCN2-mediated signaling; learning or memory; and regulation of translational initiation. Acts upstream of or within cellular response to starvation; endoplasmic reticulum unfolded protein response; and regulation of translation. Part of polysome. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and ovary. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak4 Products (3)

mRNA	Protein	Name
NM_001177806.1	NP_001171277.1	eIF-2-alpha kinase GCN2 isoform 2
NM_001355383.1	NP_001342312.1	eIF-2-alpha kinase GCN2 isoform 3
NM_013719.3	NP_038747.2	eIF-2-alpha kinase GCN2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA IDA: Inferred from direct assay	10504407	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IGI IGI: Inferred from genetic interaction	14729979	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IMP IMP: Inferred from mutant phenotype	16054071	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25329545	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10504407	MGI
enables tRNA binding	IDA IDA: Inferred from direct assay	16601681	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in GCN2-mediated signaling	IDA IDA: Inferred from direct assay	10655230	MGI
involved in GCN2-mediated signaling	IMP IMP: Inferred from mutant phenotype	11106749	MGI
involved in T cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	24310610	MGI
involved in cellular response to UV	IDA IDA: Inferred from direct assay	12176355	MGI
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	24333428	MGI
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	14729979	MGI
acts upstream of or within cellular response to starvation	IDA IDA: Inferred from direct assay	15937339	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	16176978	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	16121183	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	16121183	MGI
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	16601681	MGI
involved in negative regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16121183	MGI
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	23447528	MGI
acts upstream of or within negative regulation of translation	IGI IGI: Inferred from genetic interaction	16176978	MGI
involved in negative regulation of translational initiation	IDA IDA: Inferred from direct assay	16601681	MGI
involved in negative regulation of translational initiation in response to stress	IDA IDA: Inferred from direct assay	12176355	MGI
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	23447528	MGI
involved in positive regulation of adaptive immune response	IMP IMP: Inferred from mutant phenotype	24310610	MGI
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	16601681	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	14729979	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16121183	MGI
involved in positive regulation of translational initiation in response to starvation	IDA IDA: Inferred from direct assay	10655230	MGI
involved in positive regulation of translational initiation in response to starvation	IMP IMP: Inferred from mutant phenotype	16121183	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10655230	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10504407	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	11106749	MGI
involved in regulation of cytoplasmic translational initiation in response to stress	IDA IDA: Inferred from direct assay	24333428	MGI
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	16054071	MGI
involved in regulation of translational initiation	IGI IGI: Inferred from genetic interaction	14729979	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IDA IDA: Inferred from direct assay	10655230	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IMP IMP: Inferred from mutant phenotype	11106749	MGI
acts upstream of or within regulation of translational initiation in response to stress	IDA IDA: Inferred from direct assay	15937339	MGI
involved in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	14729979	MGI
involved in viral translation	IDA IDA: Inferred from direct assay	16601681	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23447528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
eIF-2-alpha kinase GCN2	GCN2 eIF2alpha kinase GCN2-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-148062	RSS0680	Degrader	98.03%	Unkown
HY-W319647	GCN2 activator-1	Inhibitor	99.69%	Unkown
HY-E70712	EIF2AK4 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS04247	EIF2AK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak4	NCBI	NCBI:440275