Ercc3 - ERCC excision repair 3, TFIIH core complex helicase subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291703

Summary

Predicted to enable several functions, including ATP hydrolysis activity; promoter-specific chromatin binding activity; and protein C-terminus binding activity. Involved in embryonic organ development and response to hypoxia. Located in nucleus. Part of transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc3 Products (1)

mRNA Protein Name
NM_001031644.1 NP_001026814.1 general transcription and DNA repair factor IIH helicase subunit XPB

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
involved in embryonic organ development IEP
IEP: Inferred from expression pattern
11425516 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
9763211 RGD
Cellular Component GO Annotation Evidence Verweise Source
part of transcription factor TFIIH core complex IDA
IDA: Inferred from direct assay
8855220 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

general transcription and DNA repair factor IIH helicase subunit XPB

  • DNA excision repair protein ERCC-3

  • TFIIH basal transcription factor complex helicase XPB subunit

  • TFIIH subunit XPB

  • excision repair cross-complementation group 3

  • excision repair cross-complementing rodent repair deficiency, complementation group 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-141549 BPK-21 99.56% Unkown
HY-D2331 ZL-12A probe 99.71% Unkown
HY-RS04480 ERCC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19680 Ercc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26173 Ercc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc3 NCBI NCBI:2071