Rag2 - recombination activating 2 Gene

Predicted to enable several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and zinc ion binding activity. Involved in mature B cell differentiation involved in immune response and negative regulation of T cell differentiation in thymus. Predicted to be located in nucleus. Predicted to be part of DNA recombinase complex. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Apr 2022]