Spint2 - serine protease inhibitor, Kunitz type 2 Gene

Also Known as HAI-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20733

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within basement membrane organization; chordate embryonic development; and establishment or maintenance of cell polarity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]

Spint2 Products (2)

mRNA Protein Name
NM_001082548.1 NP_001076017.1 kunitz-type protease inhibitor 2 isoform b precursor
NM_011464.2 NP_035594.1 kunitz-type protease inhibitor 2 isoform a precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
19592578 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 2

  • hepatocyte growth factor activator inhibitor type 2

Recombinant Spint2 Proteins

Cat. No. Product Name Accession Purity
HY-P76964 HAI-2 Protein, Mouse (HEK293, His) Q9WU03-2 /NP_001076017.1 (A28-K140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13686 SPINT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19530 Spint2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26025 Spint2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spint2 NCBI NCBI:10653