PPP3R2 - protein phosphatase 3 regulatory subunit B, beta Gene

Also Known as PPP3RL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5535

About PPP3R2

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,591,604-101,594,969 (from NCBI)

This gene has 2 transcripts (splice variants), 32 orthologues and 8 paralogues.

Summary

Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine Phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of Calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]

PPP3R2 Products (1)

mRNA Protein Name
NM_147180.4 NP_671709.2 calcineurin subunit B type 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein serine/threonine phosphatase regulator activity IDA
IDA: Inferred from direct assay
26429887 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3R2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (25 - 79)

EF-hand_7

EF-hand_7: EF-hand domain pair (94 - 158)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

calcineurin subunit B type 2

  • CBLP

Related Diseases

Diseases Alias
Cataract 3, Multiple Types

  • Cataract 3 Multiple Types

  • CTRCT3

  • Cca2

  • Cataract, Congenital, Cerulean Type, 2

  • Cataract 3, Multiple Types, With Or Without Microcornea

  • Cataract 3 Multiple Types With Or Without Microcornea

  • Congenital Cerulean Type Cataract 2

  • Congenital Cataract Blue Dot Type 2

  • Congenital Cataract Cerulean Type 2

  • Cspc

  • Sutural Cataract With Punctate And Cerulean Opacities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11027 PPP3R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPP3R2 MGD MGI:107171
Rattus norvegicus PPP3R2 RGD RGD:69232