Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation

  • Bioorg Med Chem Lett. 2001 Oct 22;11(20):2701-3. doi: 10.1016/s0960-894x(01)00535-2.
M F Braña  1 ,  L Añorbe ,  G Tarrasón ,  F Mitjans ,  J Piulats
Affiliations
  • 1. Departamento de Química Orgánica y Farmacéutica, Facultad de CC. Experimentales y Técnicas, Universidad San Pablo CEU, Urb. Montepríncipe, Boadilla del Monte, 28668, Madrid, Spain. [email protected]
PMID: 11591505 DOI: 10.1016/s0960-894x(01)00535-2
Abstract

A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in their structure, showed interesting activity and selectivity on HUVECs proliferation.