PCWH syndrome
Definition:
PCWH syndrome (Peripheral demyelinating neuropathy, Central dysmyelination, Waardenburg syndrome, and Hirschsprung disease) is a rare inherited disorder caused by SOX10 mutations. SOX10 regulates the development and maintenance of neural crest derivatives including Schwann cells, melanocytes, and enteric ganglion cells, and of oligodendrocytes, which are not derived from the neural crest. Accordingly, SOX10 gene mutations result in a wide spectrum of clinical phenotypes involving these cells. It is suggested that the complex neurological phenotypes in PCWH patients likely result from a combination of haploinsufficiency and additive dominant effect.
References:
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[1]. Ken Inoue, et al. Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg-Hirschsprung disease: phenotypes linked by SOX10 mutation. Ann Neurol. 2002 Dec;52(6):836-42. [Content Brief]
[2]. Yukiko Ito, et al. Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH. Neurobiol Dis. 2015 Aug;80:1-14. [Content Brief]
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