Proton-coupled folate transporter

[1]. Srinivas Aluri, et al. Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding. Biochim Biophys Acta Biomembr. 2017 Nov;1859(11):2193-2202. [Content Brief]

[2]. Joanne L Parker, et al. Structural basis of antifolate recognition and transport by PCFT. Nature. 2021 Jul;595(7865):130-134. [Content Brief]

[3]. Hongxia Li, et al. SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes. Metabolism. 2020 Sep;110:154306. [Content Brief]

[4]. Gladys O Latunde-Dada, et al. Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells. FEBS Lett. 2006 Dec 22;580(30):6865-70. [Content Brief]

[5]. Andong Qiu, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006 Dec 1;127(5):917-28. [Content Brief]

[6]. Miriam Erlacher, et al. Reversible pancytopenia and immunodeficiency in a patient with hereditary folate malabsorption. Pediatr Blood Cancer. 2015 Jun;62(6):1091-4. [Content Brief]

[7]. Tomoya Narawa, et al. Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport. Drug Metab Pharmacokinet. 2021 Dec;41:100421. [Content Brief]

[8]. Rongbao Zhao, et al. A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. J Biol Chem. 2009 Feb 13;284(7):4267-74. [Content Brief]

[9]. Srinivas Aluri, et al. Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1. Blood Adv. 2018 Jan 5;2(1):61-68. [Content Brief]

[10]. Srinivas Aluri, et al. Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation. J Biol Chem. 2019 May 3;294(18):7245-7258. [Content Brief]

[11]. Takahiro Yamashiro, et al. Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter. Sci Rep. 2019 Dec 2;9(1):18105. [Content Brief]

[12]. Rongbao Zhao, et al. Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer. Mol Pharmacol. 2018 Mar;93(3):208-215. [Content Brief]

[13]. He-Qin Zhan, et al. A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. J Biol Chem. 2020 Nov 13;295(46):15650-15661. [Content Brief]

[14]. Rongbao Zhao, et al. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62. [Content Brief]

[15]. Rongbao Zhao, et al. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood. 2007 Aug 15;110(4):1147-52. [Content Brief]

[16]. Yusuke Tozawa, et al. A deep intronic mutation of c.1166-285 T > G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM). Clin Immunol. 2019 Nov;208:108256. [Content Brief]

[17]. Bradley L Urquhart, et al. The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G248-54. [Content Brief]

[18]. Ersin Selcuk Unal, et al. The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. J Biol Chem. 2009 Jun 26;284(26):17846-57. [Content Brief]

[19]. Michele Visentin, et al. Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C631-41. [Content Brief]

[20]. Yasuhiro Nakai, et al. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. [Content Brief]

[21]. Daniel Sanghoon Shin, et al. A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. Am J Physiol Cell Physiol. 2012 May 1;302(9):C1405-12. [Content Brief]