Danger-associated molecular patterns (DAMPs)
Definition:
Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm signals by the innate immune system. DAMPs are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). DAMPs play a role in correcting the altered physiological state.
References:
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[1]. Seema Patel, et al. Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation. Curr Allergy Asthma Rep. 2018 Sep 28;18(11):63. [Content Brief]
[2]. Leslie B Tolle, et al. Danger-associated molecular patterns (DAMPs) in acute lung injury. J Pathol. 2013 Jan;229(2):145-56. [Content Brief]
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