33649-15-9
Chemical Structure
Tomentosin
- CAS No.: 33649-15-9
- Formula:C15H20O3
- Molecular Weight:248.32
IUPAC Name: (3aR,7S,8aR)-7-methyl-3-methylene-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
InChIKey: AVFIYMSJDDGDBQ-CUOATXAZSA-N
SMILES: C=C1[C@](CC=C2CCC(C)=O)([H])[C@@](OC1=O)([H])C[C@@H]2C
Biological Activity: Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases[1][2][3][4].
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Tomentosin | 98.95% | Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases. | ||||||||||||||||||||
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- [1]. Güçlü E, et al. Tomentosin induces apoptosis in pancreatic cancer cells through increasing reactive oxygen species and decreasing mitochondrial membrane potential. Toxicol In Vitro. 2022 Oct;84:105458. [Content Brief]
- [2]. Fan Y, et al. Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice. J Environ Pathol Toxicol Oncol. 2021;40(1):75-84. [Content Brief]
- [3]. Güvenç M, et al. Tomentosin mitigates the LPS induced cardiac injury by regulating Nrf-2/Nf-κβ pathway in mice. Eur J Pharmacol. 2025 Jun 5;996:177589. [Content Brief]
- [4]. Cafarchia C, et al. Attività fungistatica di un sesquiterpene lattone (tomentosina) isolato dai fiori freschi di Inula viscosa (Asteraceae) della regione Puglia [Fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh Inula viscosa (Asteraceae) flowers from the Puglia region]. Parassitologia. 2001 Sep;43(3):117-21. Italian. [Content Brief]
Keywords
