Tardbp - TAR DNA binding protein Gene

Also Known as Tdp43; TDP-43; 1190002A23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230908

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and pre-mRNA intronic binding activity. Involved in positive regulation of protein import into nucleus; regulation of circadian rhythm; and regulation of protein stability. Acts upstream of or within RNA splicing. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; amyotrophic lateral sclerosis type 10; and frontotemporal dementia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tardbp Products (6)

mRNA Protein Name
NM_001003898.3 NP_001003898.1 TAR DNA-binding protein 43 isoform 5
NM_001003899.2 NP_001003899.1 TAR DNA-binding protein 43 isoform 3
NM_001008545.2 NP_001008545.1 TAR DNA-binding protein 43 isoform 2
NM_001008546.2 NP_001008546.1 TAR DNA-binding protein 43 isoform 4
NM_001305425.1 NP_001292354.1 TAR DNA-binding protein 43 isoform 6
NM_145556.4 NP_663531.1 TAR DNA-binding protein 43 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18836447 MGI
enables pre-mRNA intronic binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22570411 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within RNA splicing IMP
IMP: Inferred from mutant phenotype
27378374 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
27378374 MGI
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
28585542 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
27123980 MGI
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
27123980 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
28585542 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TAR DNA-binding protein 43

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS23806 Tardbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14208 TARDBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17352 Tardbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tardbp NCBI NCBI:23435