Itpr3 - inositol 1,4,5-trisphosphate receptor, type 3 Gene

Also Known as IP3R3; IP3R-3; IP3R3X

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25679

Summary

Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including brush border; neuronal cell body; and nuclear outer membrane. Is active in presynapse. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]

Itpr3 Products (1)

mRNA Protein Name
NM_013138.2 NP_037270.2 inositol 1,4,5-trisphosphate receptor type 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
17320950 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10694253 RGD
enables inositol 1,3,4,5 tetrakisphosphate binding IDA
IDA: Inferred from direct assay
8388391 RGD
enables inositol 1,4,5 trisphosphate binding IDA
IDA: Inferred from direct assay
17320950 RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: Inferred from direct assay
10694253 RGD
enables inositol hexakisphosphate binding IDA
IDA: Inferred from direct assay
8388391 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21424589 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
10694253 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11788349 RGD
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
20189985 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11788349 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
8288584 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18005397 RGD
located in brush border IDA
IDA: Inferred from direct assay
8288584 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17471556 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19116207 RGD
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10096607 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15533917 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17091480 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
15537642 RGD
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
8388391 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21550988 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
10096607 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor type 3

  • IP3 receptor

  • IP3R 3

  • inositol 1,4,5-triphosphate receptor 3

  • inositol 1,4,5-triphosphate receptor, type 3

  • insP3R3

  • type 3 InsP3 receptor

  • type 3 inositol 1,4,5-trisphosphate receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06993 ITPR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21604 Itpr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28122 Itpr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpr3 NCBI NCBI:3710