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Abca7 - ATP-binding cassette, sub-family A (ABC1), member 7 Gene

Also Known as ABCX; Abc51

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27403

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. Defects in this gene cause an increase in amyloid-beta deposits in a mouse model of Alzheimer's disease, and a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jan 2017]

Abca7 Products (2)

mRNA	Protein	Name
NM_001347081.2	NP_001334010.1	ATP-binding cassette sub-family A member 7 isoform 1
NM_013850.2	NP_038878.1	ATP-binding cassette sub-family A member 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables apolipoprotein A-I receptor activity	IDA IDA: Inferred from direct assay	12917409	MGI
enables phospholipid transporter activity	IDA IDA: Inferred from direct assay	15520449	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12917409	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	27472885	MGI
involved in amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	26260791	MGI
involved in apolipoprotein A-I-mediated signaling pathway	IDA IDA: Inferred from direct assay	12917409	MGI
involved in apolipoprotein A-I-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20495215	MGI
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	27472885	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	23467355	MGI
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	27030769	MGI
involved in negative regulation of PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	27030769	MGI
involved in negative regulation of amyloid precursor protein biosynthetic process	IDA IDA: Inferred from direct assay	18429932	MGI
involved in negative regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	18429932	MGI
involved in negative regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	23467355	MGI
involved in negative regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	26260791	MGI
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	12917409	MGI
acts upstream of or within phospholipid efflux	IDA IDA: Inferred from direct assay	15520449	MGI
involved in phospholipid efflux	IMP IMP: Inferred from mutant phenotype	27472885	MGI
involved in plasma membrane raft organization	IMP IMP: Inferred from mutant phenotype	28091533	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16908670	MGI
involved in positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	23467355	MGI
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	18429932	MGI
involved in positive regulation of engulfment of apoptotic cell	IMP IMP: Inferred from mutant phenotype	16908670	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	20495215	MGI
involved in positive regulation of phospholipid efflux	IDA IDA: Inferred from direct assay	12917409	MGI
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	28091533	MGI
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	18429932	MGI
involved in regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	27030769	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	27030769	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15520449	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12917409	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	27472885	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	27472885	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	15520449	MGI
located in phagocytic cup	IDA IDA: Inferred from direct assay	16908670	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	16908670	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-binding cassette sub-family A member 7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00045	ABCA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abca7	NCBI	NCBI:10347