METTL9 - methyltransferase like 9 Gene

Also Known as DREV; PAP1; DREV1; CGI-81; hMETTL9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51108

About METTL9

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:21,597,208-21,657,471 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 199 orthologues. Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues.

Summary

Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

METTL9 Products (4)

mRNA Protein Name
NM_001077180.3 NP_001070648.1 protein-L-histidine N-pros-methyltransferase isoform 2 precursor
NM_001288659.2 NP_001275588.1 protein-L-histidine N-pros-methyltransferase isoform 3
NM_001288660.2 NP_001275589.1 protein-L-histidine N-pros-methyltransferase isoform 4
NM_016025.5 NP_057109.3 protein-L-histidine N-pros-methyltransferase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21784977 GOA
enables protein-L-histidine N-pros-methyltransferase activity IDA
IDA: Inferred from direct assay
33563959 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
33563959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL9 Protein Structure

DREV

DREV: DREV methyltransferase (56 - 317)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
Protein Preferred Names Protein Names

protein-L-histidine N-pros-methyltransferase

  • CTB-31N19.3

METTL9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
METTL9 Q9H1A3 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 22

  • DFNB22

  • Autosomal Recessive Nonsyndromic Deafness 22

  • Autosomal Recessive Deafness 22

  • Deafness, Autosomal Recessive, 22

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08371 METTL9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21884 Mettl9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28401 Mettl9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus METTL9 VGNC VGNC:31418
Mus musculus METTL9 MGD MGI:1914862
Macaca mulatta METTL9 VGNC VGNC:74568
Canis familiaris METTL9 VGNC VGNC:43183
Felis catus METTL9 VGNC VGNC:97507
Rattus norvegicus METTL9 RGD RGD:2311609
Others METTL9 NCBI