Rnf220 - ring finger protein 220 Gene

Also Known as 4732477A13; 4931406I20Rik; 5730503K05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66743

Summary

Enables ubiquitin protein Ligase activity. Involved in protein autoubiquitination. Acts upstream of or within several processes, including nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Apr 2022]

Rnf220 Products (4)

mRNA Protein Name
NM_001310729.1 NP_001297658.1 E3 ubiquitin-protein ligase Rnf220 isoform 2
NM_001310730.1 NP_001297659.1 E3 ubiquitin-protein ligase Rnf220 isoform 3
NM_001310731.1 NP_001297660.1 E3 ubiquitin-protein ligase Rnf220 isoform 4
NM_025739.3 NP_080015.3 E3 ubiquitin-protein ligase Rnf220 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20170641 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
20170641 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20170641 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
30177510 MGI
acts upstream of or within noradrenergic neuron development IMP
IMP: Inferred from mutant phenotype
32094113 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
32094113 MGI
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
20170641 MGI
acts upstream of or within protein monoubiquitination IGI
IGI: Inferred from genetic interaction
32094113 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
20170641 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
36179027 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
36179027 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
36179027 MGI
acts upstream of or within regulation of transcription regulatory region DNA binding IGI
IGI: Inferred from genetic interaction
32094113 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20170641 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
36179027 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
36179027 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
36179027 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
36179027 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
36179027 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
36179027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Rnf220

  • RING-type E3 ubiquitin transferase Rnf220

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12082 RNF220 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf220 NCBI NCBI:55182