New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals

  • Bioorg Med Chem Lett. 2002 Apr 8;12(7):1083-6. doi: 10.1016/s0960-894x(02)00069-0.
Takashi Ishiyama  1 ,  Shin Iimura ,  Satoru Ohsuki ,  Kouichi Uoto ,  Hirofumi Terasawa ,  Tsunehiko Soga
Affiliations
  • 1. Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, Tokyo R&D Center, 16-13 Kita-kasai 1-Chome Edogawa-ku, Tokyo 134-8630, Japan.
PMID: 11909723 DOI: 10.1016/s0960-894x(02)00069-0
Abstract

To synthesize new highly active taxoids, we designed and synthesized 9 beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.