2893809-52-2

(4R)-BBO-8520 Chemical Structure
2893809-52-2

Chemical Structure

(4R)-BBO-8520

  • CAS No.: 2893809-52-2
  • Formula:C35H33F6N7O2S
  • Molecular Weight:729.74

InChIKey: RIVFEDYNLHJKEZ-VHJOERAISA-N

SMILES: FC1=[C@@](C(C(F)(F)F)=CC2=C(N=C(N=C21)OC[C@@]34CCCN3C[C@@H](C4)F)N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C)[C@@]6=CC=C(F)C7=C6C(C#N)=C(N)S7

Biological Activity: (4R)-BBO-8520 (Compound 314), an isomer of BBO-8520 (HY-158107), is a selective KRAS G12C inhibitor. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRAS G12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRASG12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state. (4R)-BBO-8520 can be used for the research of cancer[1][2][3].

Cat. No. Nom du produit Pureté Description Pricing
HY-158107A 		(4R)-BBO-8520 (4R)-BBO-8520 (Compound 314), an isomer of BBO-8520 (HY-158107), is a selective KRAS G12C inhibitor. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRAS G12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRASG12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state. (4R)-BBO-8520 can be used for the research of cancer.
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