3414-47-9
Chemical Structure
U-11634
- CAS No.: 3414-47-9
- Formula:C11H10F3NO2S
- Molecular Weight:277.26
InChIKey: AIFMZFWIIGAWMP-UHFFFAOYSA-N
SMILES: FC(F)(C1=CC(OCC2OC(NC2)=S)=CC=C1)F
Biological Activity: U-11634 is an orally active dopamine β-hydroxylase noncompetitive inhibitor, with rat LD50 values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy[1][2][3][4].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
U-11634 | U-11634 is an orally active dopamine β-hydroxylase noncompetitive inhibitor, with rat LD50 values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Johnson GA, et al. Inhibition of dopamine -hydroxylase by 5-phenoxymethyl-2-oxazolidinethiones. J Med Chem. 1972 Mar;15(3):327-9. [Content Brief]
- [2]. Duncan GW, et L. The effect of U-11634 on the vaginal cytology of rats. J Reprod Fertil. 1966 Jun;11(3):459-61. [Content Brief]
- [3]. Forist AA, et al. Comparative serum levels of an antifertility oxazolidinethione (U-11634) in rats and monkeys. J Reprod Fertil. 1968 Jul;16(2):317-8. [Content Brief]
- [4]. Duncan GW, et al. The inhibition of pregnancy with an oxazolidinethione (U-11634). J. Reprod. Fertil. 1966 Feb; 11(1):85–95
Keywords
