61270-58-4
Chemical Structure
Cefonicid
- CAS No.: 61270-58-4
- Formula:C18H18N6O8S3
- Molecular Weight:542.57
IUPAC Name: (6R,7R)-7-((R)-2-hydroxy-2-phenylacetamido)-8-oxo-3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: DYAIAHUQIPBDIP-AXAPSJFSSA-N
SMILES: O=C(O)C(N12)=C(CSC3=NN=NN3CS(=O)(O)=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O
Biological Activity: Cefonicid is a long-acting cephalosporin antibiotic. Cefonicid also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid can be used for research on infections[1][2][3][4].
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Cefonicid | Cefonicid is a long-acting cephalosporin antibiotic. Cefonicid also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid can be used for research on infections. | |||||||||||||||||||||
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- [1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
- [2]. MEHTA R J, et al. Cefonicid: a stable β-lactamase inhibitor. The Journal of Antibiotics, 1981, 34(2): 202-205.
- [3]. Drago L, et al. Evaluation of antibacterial activity of cefodizime, ceftriaxone and cefonicid in Klebsiella pneumoniae-infected guinea pigs. Clinical microbiology and infection, 1999, 5(6): 371-373.
- [4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
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