66514-99-6
66514-99-6
Chemical Structure
(S)-Baclofen
- CAS No.: 66514-99-6
- Formula:C10H12ClNO2
- Molecular Weight:213.66
IUPAC Name: (S)-4-amino-3-(4-chlorophenyl)butanoic acid
InChIKey: KPYSYYIEGFHWSV-MRVPVSSYSA-N
SMILES: O=C(C[C@@H](C1=CC=C(C=C1)Cl)CN)O
Biological Activity: (S)-Baclofen is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values of 1.77 μM for GABAB and 1564 μM for GABAA. (S)-Baclofen can be used in research on muscle disorders such as spasticity[1][2].
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(S)-Baclofen | (S)-Baclofen is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values of 1.77 μM for GABAB and 1564 μM for GABAA. (S)-Baclofen can be used in research on muscle disorders such as spasticity. | |||||||||||||||||||||
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References
- [1]. Froestl W, et al. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995;38(17):3297-3312. [Content Brief]
- [2]. He Q, et al. Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 8;25(2):250. [Content Brief]
Keywords
