Lgr4 - leucine-rich repeat-containing G protein-coupled receptor 4 Gene

Also Known as Gpr48; 9130225G07; A330106J01Rik; A930009A08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107515

Summary

Enables transmembrane signaling receptor activity. Involved in several processes, including metanephros development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; eye; metanephros; nasal process; and testis. Used to study glaucoma. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Lgr4 Products (1)

mRNA Protein Name
NM_172671.2 NP_766259.2 leucine-rich repeat-containing G-protein coupled receptor 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
NOT enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
21693646 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21693646 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
21693646 MGI
Biological Process GO Annotation Evidence Références Source
involved in bone mineralization IMP
IMP: Inferred from mutant phenotype
19605502 MGI
involved in bone remodeling IMP
IMP: Inferred from mutant phenotype
19605502 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24353284 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
24353284 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
24680895 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16406039 MGI
acts upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis IGI
IGI: Inferred from genetic interaction
24680895 MGI
acts upstream of or within hair follicle development IGI
IGI: Inferred from genetic interaction
24680895 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
24680895 MGI
acts upstream of or within intestinal stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
24680895 MGI
acts upstream of or within male genitalia development IMP
IMP: Inferred from mutant phenotype
16406039 MGI
involved in metanephric glomerulus development IMP
IMP: Inferred from mutant phenotype
21523854 MGI
involved in metanephric nephron tubule morphogenesis IMP
IMP: Inferred from mutant phenotype
21523854 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24212090 MGI
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
23589304 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23589304 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19605502 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
21523854 MGI
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
21693646 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21727895 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
23393138 MGI
acts upstream of or within tube morphogenesis IMP
IMP: Inferred from mutant phenotype
16406039 MGI
Cellular Component GO Annotation Evidence Références Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21693646 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat-containing G-protein coupled receptor 4

  • G protein-coupled receptor GPR48

  • G-protein coupled receptor 48

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS25840 Lgr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07618 LGR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19349 Lgr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgr4 NCBI NCBI:55366