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CPLX1 - complexin 1 Gene

Also Known as CPX1; CPX-I; DEE63; EIEE63

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10815

About CPLX1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:784,957-826,129 (from NCBI)

This gene has 4 transcripts (splice variants), 115 orthologues, 3 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 19.8), fat (RPKM 3.8) and 5 other tissues.

Summary

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

CPLX1 Products (1)

mRNA	Protein	Name
NM_006651.4	NP_006642.1	complexin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21785412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPLX1 Protein Structure

Synaphin

0
100
134 a.a.

Protein Preferred Names	Protein Names
complexin-1	CPX I

CPLX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CPLX1	O14810	SNAP25	Homo sapiens	P60880-2	FRET	21785412
Intra	CPLX1	O14810	SNAP25	Homo sapiens	P60880-2	X-Ray Diffraction	21785414
Intra	CPLX1	O14810	SNAP25	Homo sapiens	P60880-2	FRET	21785414
Intra	CPLX1	O14810	SNAP25	Homo sapiens	P60880-2	GMS	21785412
Intra	CPLX1	O14810	SNAP25	Homo sapiens	P60880-2	GMS	21785414

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 63	DEE63 Epileptic Encephalopathy, Early Infantile, 63 Eiee63 Developmental And Epileptic Encephalopathy, 63 Early Infantile Epileptic Encephalopathy 63 Encephalopathy, Epileptic, Early Infantile, Type 63
Myoclonic Epilepsy, Familial Infantile	Familial Infantile Myoclonic Epilepsy FIME Eim Myoclonic Epilepsy, Infantile, Familial Familial Infantile Myoclonus Epilepsy Epilepsy, Myoclonic, Infantile, Familial Epilepsy, Myoclonic, Infantile
Chromosome 4p Deletion	4p Partial Monosomy Syndrome Chromosome 4 Short Arm Deletion 4p Deletion 4p Monosomy Deletion 4p Monosomy 4p Partial Monosomy 4p Wolf-Hirschhorn Syndrome Chromosome 4 Short Arm Deletion Syndrome Deletion Of Short Arm Of Chromosome 4
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03097	CPLX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22455	Cplx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28978	Cplx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CPLX1	VGNC	VGNC:71460
Rattus norvegicus	CPLX1	RGD	RGD:70944
Bos taurus	CPLX1	VGNC	VGNC:58459
Canis familiaris	CPLX1	VGNC	VGNC:39555
Mus musculus	CPLX1	MGD	MGI:104727
Felis catus	CPLX1	VGNC	VGNC:107321