Lmo4 - LIM domain only 4 Gene

Also Known as Crp3; Etohi4; A730077C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16911

Summary

Predicted to enable metal ion binding activity. Involved in positive regulation of kinase activity and regulation of cell migration. Acts upstream of or within several processes, including cell differentiation in spinal cord; neural tube closure; and thymus development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study anencephaly. Orthologous to human LMO4 (LIM domain only 4). [provided by Alliance of Genome Resources, Apr 2022]

Lmo4 Products (3)

mRNA Protein Name
NM_001161769.1 NP_001155241.1 LIM domain transcription factor LMO4
NM_001161770.1 NP_001155242.1 LIM domain transcription factor LMO4
NM_010723.3 NP_034853.1 LIM domain transcription factor LMO4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16949565 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9860983 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
18539116 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
9860983 MGI
Biological Process GO Annotation Evidence Références Source
involved in motor neuron axon guidance IGI
IGI: Inferred from genetic interaction
18539116 MGI
acts upstream of or within negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
19666821 MGI
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
18539116 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18539116 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
14966285 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
16949565 MGI
involved in positive regulation of kinase activity IDA
IDA: Inferred from direct assay
25882817 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17991461 MGI
acts upstream of or within regulation of cell activation IMP
IMP: Inferred from mutant phenotype
19323994 MGI
acts upstream of or within regulation of cell fate specification IMP
IMP: Inferred from mutant phenotype
19323994 MGI
involved in regulation of cell migration IDA
IDA: Inferred from direct assay
25882817 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9860983 MGI
acts upstream of or within spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
19323994 MGI
involved in spinal cord motor neuron cell fate specification IMP
IMP: Inferred from mutant phenotype
18539116 MGI
acts upstream of or within spinal cord motor neuron differentiation IDA
IDA: Inferred from direct assay
19666821 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
20549734 MGI
acts upstream of or within ventral spinal cord interneuron differentiation IDA
IDA: Inferred from direct assay
19666821 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
20549734 MGI
Cellular Component GO Annotation Evidence Références Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
9860983 MGI
located in cell leading edge IDA
IDA: Inferred from direct assay
25882817 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9860983 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM domain transcription factor LMO4

  • LIM domain only protein 4

  • LMO-4

  • breast tumor autoantigen

  • ethanol induced 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03260 CSRP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07720 LMO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20768 Lmo4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27282 Lmo4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmo4 NCBI NCBI:8543