Ntf3 - neurotrophin 3 Gene

Also Known as Nt3; HDNF; NGF-2; Ntf-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18205

Summary

This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane Receptor Tyrosine Kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]

Ntf3 Products (5)

mRNA Protein Name
NM_001164034.2 NP_001157506.1 neurotrophin-3 isoform a
NM_001164035.2 NP_001157507.1 neurotrophin-3 isoform a
NM_001410128.1 NP_001397057.1 neurotrophin-3 isoform b preproprotein
NM_001410129.1 NP_001397058.1 neurotrophin-3 isoform c
NM_008742.4 NP_032768.1 neurotrophin-3 isoform b preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11684666 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
15550985 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
8861722 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
10195193 MGI
acts upstream of or within enteric nervous system development IMP
IMP: Inferred from mutant phenotype
15497153 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
9736028 MGI
acts upstream of or within generation of neurons IGI
IGI: Inferred from genetic interaction
16142215 MGI
acts upstream of or within glial cell fate determination IMP
IMP: Inferred from mutant phenotype
10384880 MGI
acts upstream of or within mechanoreceptor differentiation IGI
IGI: Inferred from genetic interaction
15376326 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19915564 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
7605630 MGI
acts upstream of or within neuromuscular synaptic transmission IDA
IDA: Inferred from direct assay
11978828 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19915564 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
8809809 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
8630254 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12741988 MGI
acts upstream of or within regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16516892 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
15497153 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14715936 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurotrophin-3

  • nerve growth factor 2

  • neurotrophic factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09616 NTF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20313 Ntf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26821 Ntf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntf3 NCBI NCBI:4908