WAPL - WAPL cohesin release factor Gene

Also Known as FOE; WAPAL; KIAA0261

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23063

About WAPL

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,435,256-86,521,792 (from NCBI)

This gene has 4 transcripts (splice variants) and 295 orthologues. Ubiquitous expression in testis (RPKM 17.0), lymph node (RPKM 9.9) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

WAPL Products (2)

mRNA	Protein	Name
NM_001318328.2	NP_001305257.1	wings apart-like protein homolog isoform 2
NM_015045.5	NP_055860.1	wings apart-like protein homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP-dependent protein-DNA unloader activity	IMP IMP: Inferred from mutant phenotype	17113138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17112726	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	17113138	GOA
involved in negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19907496	GOA
involved in negative regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	17113138	GOA
involved in negative regulation of sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	19696148	GOA
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	21111234	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IDA IDA: Inferred from direct assay	17113138	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17113138	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17113138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WAPL Protein Structure

WAPL

0
200
400
600
800
1000
1190 a.a.

Protein Preferred Names	Protein Names
wings apart-like protein homolog	friend of EBNA2 (Epstein-Barr virus nuclear protein 2)

WAPL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Pull Down	25173175
Intra	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	TAP	20360068
Intra	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17113138
Intra	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17112726
Intra	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17113138
Intra	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17112726
Intra	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	TAP	20360068
Intra	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Cosedimentation	17113138
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17112726
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Tag CoIP	26496610
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Tag CoIP	35271311
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	TAP	20360068
Intra	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Pull Down	25173175

Cross: Cross-species interaction Intra: Intraspecies interaction

WAPL Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82652	WAPL Antibody (YA2397)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Warsaw Breakage Syndrome	WABS WBRS
Chronic Atrial And Intestinal Dysrhythmia	CAID Caid Syndrome Cohesinopathy Affecting Heart And Gut Rhythm Chronic Atrial Intestinal Dysrhythmia Syndrome Chronic Atrial And Intestinal Dysrhythmia Syndrome Chronic Atrial Dysrhythmia-Intestinal Motility Disorder Dysrhythmia, Atrial And Intestinal, Chronic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15738	WAPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WAPL	VGNC	VGNC:36862
Rattus norvegicus	WAPL	RGD	RGD:1590924
Macaca mulatta	WAPL	VGNC	VGNC:79384
Mus musculus	WAPL	MGD	MGI:2675859
Canis familiaris	WAPL	VGNC	VGNC:48330
Felis catus	WAPL	VGNC	VGNC:66998
Others	WAPL	NCBI