ADAM2 - ADAM metallopeptidase domain 2 Gene

Also Known as CT15; FTNB; PH30; CRYN1; CRYN2; PH-30b; PH30-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2515

About ADAM2

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:39,743,735-39,838,227 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 361 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 28.4).

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

ADAM2 Products (3)

mRNA Protein Name
NM_001278113.2 NP_001265042.1 disintegrin and metalloproteinase domain-containing protein 2 isoform 2 precursor
NM_001278114.2 NP_001265043.1 disintegrin and metalloproteinase domain-containing protein 2 isoform 3 precursor
NM_001464.5 NP_001455.3 disintegrin and metalloproteinase domain-containing protein 2 isoform 1 preproprotein

ADAM2 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (39 - 141)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (178 - 375)

Disintegrin

Disintegrin: Disintegrin (393 - 470)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (474 - 588)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 2

  • cancer/testis antigen 15

Related Diseases

Diseases Alias
Meckel Syndrome, Type 3

  • MKS3

  • Meckel Syndrome 3

  • Meckel-Gruber Syndrome, Type 3

  • Meckel Syndrome Type 3
Severe Congenital Neutropenia 4

  • Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

  • Scn4

  • Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

  • Dursun Syndrome

  • Severe Congenital Neutropenia Type 4
Gait Apraxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00276 ADAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22377 Adam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28901 Adam2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADAM2 VGNC VGNC:55029
Macaca mulatta ADAM2 VGNC VGNC:83976
Rattus norvegicus ADAM2 RGD RGD:69299
Mus musculus ADAM2 MGD MGI:1340894
Felis catus ADAM2 VGNC VGNC:59579
Others ADAM2 NCBI