OSBPL3 - oxysterol binding protein like 3 Gene

Also Known as ORP3; ORP-3; OSBP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26031

About OSBPL3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:24,796,537-24,981,845 (from NCBI)

This gene has 14 transcripts (splice variants), 276 orthologues and 11 paralogues. Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin Cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

OSBPL3 Products (4)

mRNA Protein Name
NM_015550.4 NP_056365.1 oxysterol-binding protein-related protein 3 isoform a
NM_145320.2 NP_663160.1 oxysterol-binding protein-related protein 3 isoform b
NM_145321.2 NP_663161.1 oxysterol-binding protein-related protein 3 isoform c
NM_145322.2 NP_663162.1 oxysterol-binding protein-related protein 3 isoform d

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
17428193 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
14593528 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
14593528 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
14593528 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14593528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL3 Protein Structure

PH_8

PH_8: Pleckstrin homology domain (56 - 143)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (527 - 869)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 3

  • OSBP-related protein 3

OSBPL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
OSBPL3 Q9H4L5 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Cross
OSBPL3 Q9H4L5 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
OSBPL3 Q9H4L5 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Erythrokeratodermia Variabilis Et Progressiva 1

  • Erythrokeratodermia Variabilis

  • Erythrokeratodermia Variabilis Et Progressiva

  • Greither Disease

  • Ekv

  • Ekvp

  • PSEK

  • Erythrokeratodermia Variabilis With Erythema Gyratum Repens

  • Keratosis Palmoplantaris Transgrediens Et Progrediens

  • Transgrediens Et Progrediens Palmoplantar Keratoderma

  • EKVP1

  • Erythrokeratodermia, Progressive Symmetric

  • Erythrokeratodermia Figurata, Congenital Familial, In Plaques

  • Keratoderma Palmoplantaris Transgrediens

  • Keratosis Extremitatum Hereditaria Progrediens

  • Erythrokeratodermia Variabilis, Mendes Da Costa Type

  • Progressive Symmetric Erythrokeratodermia

  • Erythrokeratodermia Figurata Variabilis

  • Greither'S Disease

  • Ekv-P

  • Erythrokeratodermia Variabilis Of Mendes Da Costa

  • Progressive Symmetrical Erythrokeratoderma Of Gottron

  • Progressive Diffuse Ppk

  • Progressive Diffuse Palmoplantar Keratoderma

  • Transgrediens Et Progrediens Ppk

  • Darier-Gottron Disease

  • Erythrokeratodermia Progressiva Symmetrica

  • Progressive Symmetric Erythrokeratodermia, Gottron Type

  • Congenital Familial Erythrokeratodermia Figurata In Plaques

  • Erythrokeratodermia Progressive Symmetric

  • Erythrokeratodermia Variabilis Mendes Da Costa Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09841 OSBPL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20575 Osbpl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27083 Osbpl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus OSBPL3 VGNC VGNC:63979
Canis familiaris OSBPL3 VGNC VGNC:44155
Bos taurus OSBPL3 VGNC VGNC:32462
Rattus norvegicus OSBPL3 RGD RGD:1564287
Mus musculus OSBPL3 MGD MGI:1918970
Macaca mulatta OSBPL3 VGNC VGNC:75623
Others OSBPL3 NCBI