Uts2 - urotensin 2 Gene

Also Known as Ucn2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29180

Summary

Predicted to enable hormone activity. Involved in several processes, including negative regulation of secretion; regulation of blood pressure; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Apr 2022]

Uts2 Products (1)

mRNA Protein Name
NM_019160.2 NP_062033.1 urotensin-2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Références Source
involved in blood vessel diameter maintenance IDA
IDA: Inferred from direct assay
17097764 RGD
involved in negative regulation of blood pressure IDA
IDA: Inferred from direct assay
12217424 RGD
involved in negative regulation of glomerular filtration IDA
IDA: Inferred from direct assay
16531985 RGD
involved in negative regulation of heart rate IDA
IDA: Inferred from direct assay
12217424 RGD
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17931748 RGD
involved in negative regulation of urine volume IDA
IDA: Inferred from direct assay
16531985 RGD
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
17089015 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
12217424 RGD
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
18475149 RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep IDA
IDA: Inferred from direct assay
15944374 RGD
involved in positive regulation of circadian sleep/wake cycle, wakefulness IDA
IDA: Inferred from direct assay
15944374 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
17184580 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
18082287 RGD
involved in positive regulation of fibroblast migration IDA
IDA: Inferred from direct assay
18475149 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
17184580 RGD
involved in positive regulation of heart rate IDA
IDA: Inferred from direct assay
12217424 RGD
involved in positive regulation of synaptic transmission, cholinergic IDA
IDA: Inferred from direct assay
15944374 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16677483 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
12421619 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17184580 RGD
Cellular Component GO Annotation Evidence Références Source
located in extracellular space IDA
IDA: Inferred from direct assay
17184580 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

urotensin-2

  • U-II

  • UII

  • urocortin 2

  • urotensin II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15583 UTS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15584 UTS2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15585 Uts2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15586 Uts2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20833 Uts2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27347 Uts2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uts2 NCBI NCBI:10911