Ndufc2 - NADH:ubiquinone oxidoreductase subunit C2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 293130

Summary

Involved in several processes, including mitochondrial respiratory chain complex I assembly; negative regulation of NIK/NF-kappaB signaling; and positive regulation of ATP biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to several human genes including NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2). [provided by Alliance of Genome Resources, Apr 2022]

Ndufc2 Products (1)

mRNA Protein Name
NM_001009290.1 NP_001009290.1 NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Références Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
26888427 RGD
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
26888427 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
26888427 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
26888427 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
26888427 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 subunit C2

  • NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09156 NDUFC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21897 Ndufc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28414 Ndufc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufc2 NCBI NCBI:4718