UBAC2 - UBA domain containing 2 Gene

Also Known as PHGDHL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 337867

About UBAC2

This gene has 11 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 8.2), thyroid (RPKM 7.2) and 25 other tissues.

Summary

Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Acts upstream of or within protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

UBAC2 Products (2)

mRNA	Protein	Name
NM_001144072.2	NP_001137544.1	ubiquitin-associated domain-containing protein 2 isoform 1 precursor
NM_177967.4	NP_808882.1	ubiquitin-associated domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22119785	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	31073040	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
acts upstream of or within protein localization to endoplasmic reticulum	IDA IDA: Inferred from direct assay	23297223	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23297223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAC2 Protein Structure

UBA

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
ubiquitin-associated domain-containing protein 2	RP11-178C10.1

UBAC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	UBAC2	Q8NBM4	FAF2	Homo sapiens	Q96CS3	Pull Down	22119785
Intra	UBAC2	Q8NBM4	FAF2	Homo sapiens	Q96CS3	Anti Bait CoIP	22119785
Intra	UBAC2	Q8NBM4	FAF2	Homo sapiens	Q96CS3	Anti Tag CoIP	28514442
Intra	UBAC2	Q8NBM4	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Hypopyon
Photoallergic Dermatitis	Dermatitis, Photoallergic Photoallergic Contact Dermatitis Photoallergic Eczema Photo-Allergic Contact Eczema

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15327	UBAC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBAC2	VGNC	VGNC:102355
Rattus norvegicus	UBAC2	RGD	RGD:1311689
Macaca mulatta	UBAC2	VGNC	VGNC:106308
Bos taurus	UBAC2	VGNC	VGNC:36568
Canis familiaris	UBAC2	VGNC	VGNC:48043
Mus musculus	UBAC2	MGD	MGI:1916139
Others	UBAC2	NCBI