EMC7 - ER membrane protein complex subunit 7 Gene

Also Known as HT022; C11orf3; C15orf24; ORF1-FL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56851

About EMC7

This gene has 4 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 46.7), adrenal (RPKM 45.9) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC7 Products (1)

mRNA Protein Name
NM_020154.3 NP_064539.1 ER membrane protein complex subunit 7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
Cellular Component GO Annotation Evidence Références Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32439656 GOA
located in membrane IDA
IDA: Inferred from direct assay
22119785 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC7 Protein Structure

DUF2012

DUF2012: Protein of unknown function (DUF2012) (57 - 168)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 7

  • UPF0480 protein C15orf24

EMC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EMC7 Q9NPA0 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
EMC7 Q9NPA0 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
EMC7 Q9NPA0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
EMC7 Q9NPA0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
EMC7 Q9NPA0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
EMC7 Q9NPA0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
EMC7 Q9NPA0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
EMC7 Q9NPA0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
EMC7 Q9NPA0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
EMC7 Q9NPA0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
EMC7 Q9NPA0 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
EMC7 Q9NPA0 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nodular Hidradenoma

  • Eccrine Nodular Hidradenoma

  • Eccrine Acrospiroma
Eccrine Acrospiroma

  • Acrospiroma

  • Poroma

  • Eccrine Hidradenoma

  • Eccrine Hidradenoma Of Skin

  • Hidradenoma

  • Adenoma, Sweat Gland

  • Benign Neoplasm Of Sweat Gland

  • Eccrine Poroma
Eccrine Sweat Gland Neoplasm

  • Eccrine Skin Neoplasm

  • Eccrine Tumor

  • Eccrine Neoplasm

  • Malignant Eccrine Neoplasm
Hidradenoma

  • Adenoma, Sweat Gland

  • Hidradenoma Of Skin

  • Sweat Gland Adenoma

  • Syringoadenoma

  • Eccrine Acrospiroma

  • Benign Neoplasm Of Sweat Gland
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04341 EMC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EMC7 MGD MGI:1920274
Canis familiaris EMC7 VGNC VGNC:40336
Bos taurus EMC7 VGNC VGNC:55112
Rattus norvegicus EMC7 RGD RGD:1305045
Felis catus EMC7 VGNC VGNC:61837
Macaca mulatta EMC7 VGNC VGNC:72094
Others EMC7 NCBI