5,6:8,9-diepoxy and other cytotoxic sterols from the marine sponge Homaxinella sp

  • J Nat Prod. 2006 Jan;69(1):131-4. doi: 10.1021/np0502950.
Tayyab A Mansoor  1 ,  Yoon Mi Lee ,  Jongki Hong ,  Chong-O Lee ,  Kwang Sik Im ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 16441084 DOI: 10.1021/np0502950
Abstract

Four new (1, 2, 4, and 5) and 14 known (3 and 6-18) polyoxygenated sterols have been isolated from the MeOH extract of the marine Sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-Diepoxy sterols (1-3) were isolated from a marine organism for the first time. The isolated sterols were tested against a panel of five human solid tumor cell lines and exhibited varying degrees of cytotoxicity.

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