Synthesis and antitumor activity of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside analogues

  • Eur J Med Chem. 2010 Jul;45(7):3219-22. doi: 10.1016/j.ejmech.2010.03.038.
Jin-Lan Yu  1 ,  Qin-Pei Wu ,  Qing-Shan Zhang ,  Xiao-Dong Xi ,  Ning-Ning Liu ,  Yun-Zheng Li ,  Yan-Hong Liu ,  Hong-Quan Yin
Affiliations
  • 1. Department of Applied Chemistry and Pharmacy, Beijing Institute of Technology, Nandajie 5, Beijing 100081, P.R. China.
PMID: 20409617 DOI: 10.1016/j.ejmech.2010.03.038
Abstract

A series of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.